When Will the Outbreak Be Over?

At the Atlantic Alexis C. Madrigal reflects on when the outbreak of COVID-19 will be over in the U. S.:

The most obvious interpretation of “beating COVID-19” would be that transmission of the coronavirus has stopped, a scenario some public-health experts have hashtagged #ZeroCOVID. But the experts I spoke with all agreed that this won’t happen in the U.S. in the foreseeable future. “This would require very high levels of vaccination coverage,” said Celine Gounder, an infectious-disease specialist at NYU who served on Joe Biden’s coronavirus task force during the transition. The U.S. may never reach vaccination rates of 75 to 85 percent, the experts said.

“The question is not when do we eliminate the virus in the country,” said Paul Offit, the director of the Vaccine Education Center and an expert in virology and immunology at the Children’s Hospital of Philadelphia. Rather, it’s when do we have the virus sufficiently under control. “We’ll have a much, much lower case count, hospitalization count, death count,” Offit said. “What is that number that people are comfortable with?” In his view, “the doors will open” when the country gets to fewer than 5,000 new cases a day, and fewer than 100 deaths.

That latter threshold, of 100 COVID-19 deaths a day, was repeated by other experts, following the logic that it approximates the nation’s average death toll from influenza. In most recent years, the flu has killed 20,000 to 50,000 Americans annually, which averages out to 55 to 140 deaths a day, said Joseph Eisenberg, an epidemiologist at the University of Michigan. “This risk was largely considered acceptable by the public,” Eisenberg said. Monica Gandhi, an infectious-disease specialist at UC San Francisco, made a similar calculation. “The end to the emergency portion of the pandemic in the United States should be heralded completely by the curtailing of severe illness, hospitalizations, and deaths from COVID-19,” she said. “Fewer than 100 deaths a day—to mirror the typical mortality of influenza in the U.S. over a typical year—is an appropriate goal.”

Another yardstick that has been proposed is by number of newly-diagnosed cases:

Some experts were even more conservative. Crystal Watson, a health-security scholar at Johns Hopkins University, suggested a threshold of 0.5 newly diagnosed cases per 100,000 people every day, and a test-positivity rate of less than 1 percent. That would translate to fewer than 2,000 cases a day in the U.S., compared with the current 60,000 or more. We’d also want to log at least one month of normal hospital operations without staff or equipment shortages, she said.

which I find a bit facetious. As the ability to diagnose cases becomes more effective shouldn’t it shorten the duration of the outbreak? That wouldn’t necessarily be the case.

You would think that after nearly a year of a global pandemic there might be more agreement about when it was no longer a pandemic and when local outbreaks were over. Apparently not. Keep in mind that in some countries, e.g. New Zealand, Australia, and Singapore, the outbreaks are already materially over. In other, including the U. S., it will certainly be many months and might even be years before the present outbreaks are over. That in turn implies that, unless much more stringent bans on international travel are imposed than have been the case to date, the global pandemic will not be over for a very long time.

4 comments… add one
  • PD Shaw Link

    Offit’s view is the correct one here. Vaccines are not generally eradicating; I wonder if Celine Gounder was asked the same question as others. I also doubt Watson’s metric has any meaning; we’ll probably hit 2,000 cases a day by July, but a lot of cases will be undetected.

    I think the question really being asked is when will things get back to normal. Illinois’ governor has said he will voluntarily relinquish his emergency powers when a vaccine is widely available to those who want it. That seems more like a moral standard than an epidemiological one, but that’s probably when the emergency is over, and it will probably be different in different places.

  • we’ll probably hit 2,000 cases a day by July, but a lot of cases will be undetected.

    That’s why I’ve expressed skepticism of using test positivity rates for any purpose whatever. If we’d been doing epidemiological testing all along it would be one things but we haven’t. We have no empirically based notion of the prevalence of the disease.

  • Thomas W Lindmark Link

    Or it will be over in what will seem like a sudden occurrence. The Spanish Flu raged for a couple of years and then disappeared. Likewise SARS and other virus outbreaks of the past few decades have appeared, raged and then faded into the background. It’s the nature of viruses. They can mutate to cause worse harm or mutate to relative insignificance.
    We simply don’t know how this will or if it will end.

  • steve Link

    If we can get the vaccines and if the virus doesnt mutate more, I think we could be there by late spring. We should have the most at risk people vaccinated by then and we should have enough that it will be easy to keep R below 1.

    Steve

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