You may not be familiar with the name of Donald Henderson. Dr. Henderson was an epidemiologist and is one of those credited with eradicating smallpox. I wanted to pass along a quote of his I stumbled across:
The interest in quarantine reflects the views and conditions prevalent more than 50 years ago, when much less was known about the epidemiology of infectious diseases and when there was far less international and domestic travel in a less densely populated world. It is difficult to identify circumstances in the past half-century when large-scale quarantine has been effectively used in the control of any disease. The negative consequences of large-scale quarantine are so extreme (forced confinement of sick people with the well; complete restriction of movement of large populations; difficulty in getting critical supplies, medicines, and food to people inside the quarantine zone) that this mitigation measure should be eliminated from serious consideration.
I do not pass this along as dispositive but as evidence that epidemiologists do not speak with one voice on this subject.